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Monday, March 30th 2009 at 4:08 am
[...] Anti-inflammatory medications are of two types: steroidal and nonsteroidal. It may seem odd that steroids, which in high concentrations can damage the hippocampus, can be therapeutic for patients with dementia. However, the fact that inflammation does occur in the brains of these patients suggests that steroids, which have extremely powerful anti-inflammatory properties, may indeed be effective treatments. Drs. Paul Aisen and Ken Davis at the Mount Sinai Medical Center in New York certainly think so, and they recently completed a placebo-controlled clinical trial using prednisone, a synthetic steroid, in Alzheimer’s disease. However, the trial results were negative: prednisone showed no advantage over placebo in these patients. [...]